Characterization of a spinal, urine storage reflex, inhibitory center and its regulation by 5-HT1A receptors in female cats.

Editorial Focus: Spinal Interneurons and Micturition Reflexes: Focus on “Characterization of a Spinal-Urine Storage Reflex- Inhibitory Center (SUSRIC) and its Regulation by Serotonin 5-HT1A Receptors in Female Cats”

Characterization of a “Spinal - Urine Storage Reflex - Inhibitory Center” (SUSRIC) and Its Regulation by Serotonin 5-HT1A Receptors in Female Cats

Urine storage is facilitated by somatic (pudendal nerve, PUD) and sympathetic (hypogastric nerve, HgN) reflexes to the urethral rhabdosphincter (URS) and urethral smooth muscle, respectively, initiated by primary afferent fibers in the pelvic nerve (PEL). Inhibition of storage reflexes is required for normal voiding. This study characterizes a urine storage reflex inhibitory network that can be...

Spinal interneurons and micturition reflexes: focus on "Characterization of a spinal, urine storage reflex, inhibitory center and its regulation by 5-HT1A receptors in female cats".

GENERATIONS OF EFFORT HAVE been devoted to understanding how the human body stores and periodically releases urine. Micturition is regulated by neural circuits in the brain and spinal cord that coordinate the activity of the smooth and striated muscles of the lower urinary tract (LUT) (7, 9, 10, 12). These circuits act as on/off switches to shift the urinary tract between two modes of operation...

Characterization of a descending system that enables crossed group II inhibitory reflex pathways in the cat spinal cord.

In the cat, stimulation of group II afferents from hindlimb muscles evokes different crossed reflex actions depending on the integrity of the spinal cord: with the cord intact, extensor motoneurons are inhibited by activation of contralateral group II afferents; after spinal transection, the same stimuli excite these neurons (crossed extension reflex). We have investigated the mechanisms underl...

Effect of Several 5-Hydroxytryptamine1A Receptor Ligands on the Micturition Reflex in Rats: Comparison with WAY

Several novel N-arylpiperazine derivatives were synthesized and tested for their 1) affinity and functional activity on 5-hydroxytryptamine1A (5-HT1A) receptors in vitro; 2) activity in models predictive of antagonism at somatodendritic and postsynaptic 5-HT1A receptors; and 3) effects on the micturition reflex in anesthetized and conscious rats. These studies also included 1-(2-methoxyphenyl)-...